ZIMHI – 5 mg Naloxone IM

November 20, 2020 0 Comments

Adamis prescription drugs is searching for FDA approval for ZIMHI™(naloxone) Injection, a 5(FIVE) milligram IM dose of naloxone to be used in suspected opioid overdose.


In EMS, we attempt to titrate naloxone to the smallest doable quantity to scale back respiratory melancholy.  Now we have that luxurious as a result of we stock bag valve masks, which allow us to breathe for apneic or agonal sufferers till they can ventilate on their very own. 

Just a few years in the past ADAPT prescription drugs got here out with a four mg intranasal product, NARCAN.  Our native hearth and police departments began carrying it, and we began exhibiting up on scene simply in time for the victims to take a seat bolt upright and projectile vomit on us.

four mg intranasal is roughly equal to 2 mg IM based mostly on bioavailability.

The one time I’ve ever given 2 mg IM in a single shot is when I’ve a affected person who will not be solely apneic, however cyanotic and I’m having issue discovering a pulse.  Apart from that, I take advantage of a lessor quantity.  My most popular dose in these affected person I can achieve IV entry on, is 0.1 mg IV Q 1 minute till respirations decide up.

5 mg IM goes to trigger some severe opioid withdrawal syndrome in overdosed folks with historical past of opioid use.  I imagine it might be prison to permit EMS to hold and administer such doses.  I’ve a distinct view relating to layperson administration.

I assist administer Connecticut’s SWORD program, the place EMS calls in to the Connecticut Poison Management Middle after every opioid overdose they reply to and supply solutions to numerous questions, together with how a lot naloxone the affected person acquired, who gave it, and whether or not or not there have been ant unintended effects.  I’ve learn over 8,000 of those experiences.  It isn’t unusual for overdose victims to obtain 8, 12, 16 and even 24 mgs of naloxone from laypeople.  As a result of naloxone doesn’t instantly resuscitate folks and when you’re standing subsequent to somebody who’s blue, I feel there’s a tendency of laypeople to only unload every thing they’ve as a result of they don’t know what else to do.

It’s arduous to argue that placing somebody into withdrawal is worse than not restoring their respiratory in the event you lack capability to breathe for the particular person whereas ready for the naloxone to kick in.

You may give the excessive doses to put folks.  Simply hold the supercharged doses out of EMS drug packing containers.

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